SCOTTISH SCIENTISTS IN BREAKTHROUGH ON DANGER GENES

SCOTTISH scientists have made a breakthrough that could see people undergo “genetic testing” to see if they will develop illnesses such as cancer or Parkinson’s disease in later life.

http://ping.fm/GnMkQ

The Truth About the Health Benefits of Tea

The way scientific studies and health gurus alike have touted the perks of tea over the past few years, you'd think the stuff was some kind of all-powerful magical elixir. Improving heart health, reducing cancer risk, warding off dementia and diabetes — there's barely a health benefit that hasn't been credited to tea.

http://ping.fm/trQdd

No extra restless legs syndrome in Parkinson's

Contrary to previous findings, a new study hints that restless legs syndrome, or RLS, is not more common in people with early Parkinson's disease.
http://ping.fm/JXxeT

NIH-funded twin study finds occupational chemical exposure may be linked to Parkinson's risk

A new research report contributes to the increasing evidence that repeated occupational exposure to certain chemical solvents raises the risk for Parkinson's disease. Researchers analyzed the occupational histories of twins in which one of the pair developed the neurodegenerative disorder, and assessed that twin's likelihood of exposure to six chemicals previously linked to Parkinson's.

http://ping.fm/quzmV

Parkinsonian Worms May Hold the Key to Identifying Drugs for Parkinson’s Disease

Researchers at The University of Texas at Austin have devised a simple test, using dopamine-deficient worms, for identifying drugs that may help people with Parkinson’s disease.

http://ping.fm/NO2n5

New Parkinson’s therapies aim to halt disease, not just symptoms

The introduction of levadopa therapy more than 40 years ago marked a milestone in the treatment of Parkinson’s disease. The dopamine replacement drug helps control the motor symptoms associated with the neurodegenerative disease, but it does not prevent the further loss of dopamine-producing neurons, so researchers have been on the hunt for more neuroprotective treatment options.

http://ping.fm/NIFT2

Nutrition for Parkinson's Disease
Constipation, urinary tract infections (UTIs), thinning bones, and unexplained weight loss are all common in persons with Parkinson’s Disease (PD). Preventing or managing these conditions can be accomplished through proper hydration and nutritional intake.

http://ping.fm/YRVe0

Focus on 'invisible' Parkinson's symptoms

Tremors are perhaps the most well known symptom associated with Parkinson's disease (PD). However, a new campaign is aiming to raise awareness of some of the lesser known symptoms associated with this condition.

http://ping.fm/vdHIj

New class of Canine Partners

The dogs assist people in Chester County who have mobility or balance issues stemming from a variety of ailments, including muscular dystrophy, spina bifida, multiple sclerosis, ALS, Parkinson's disease, epilepsy and even autism.

http://ping.fm/Vwl9Q

Common brain parasite 'can affect host's actions'

Boffins here in Blighty say that a brain parasite which is carried by up to 20 per cent of the population is capable of affecting its host's actions for its own benefit – but against the interests of the host.

http://ping.fm/ew1oe

Nothing like mother’s milk: potential treatments from stem cells in breast milk

Researchers have identified stem cells in human breast milk, which behave similarly to embryonic stem cells when cultivated in a medium containing nutrients.

http://ping.fm/dV3Qp

Eating right with Parkinson's disease

While there is no special diet required for people with Parkinson's disease, eating a well-balanced, nutritious diet is extremely beneficial. With the proper diet, our bodies work more efficiently, we have more energy, and Parkinson's disease medications will work properly.

http://ping.fm/Y8GUM

Exercise safety and Parkinson's Disease
Because Parkinson's disease affects your ability to move, exercise helps to keep muscles strong and improve flexibility and mobility. Exercise will not stop Parkinson's disease from progressing; but, it will improve your balance and it can prevent joint stiffening.
http://ping.fm/Z6CGo

Structure of Parkinson's disease protein identified

A team of researchers from the Petsko-Ringe and Pochapsky laboratories at Brandeis have produced and determined the structure of alpha-synuclein, a key protein associated with Parkinson’s disease.

http://ping.fm/WNIYd

Abnormal oscillation in the brain causes motor deficits in Parkinson's disease

The research group headed by Professor Atsushi Nambu (The National Institute for Physiological Sciences) and Professor Masahiko Takada (Primate Research Institute, Kyoto University) has shown that the 'oscillatory' nature of electrical signals in subcortical nuclei, the basal ganglia, causes severe motor deficits in Parkinson's disease, by disturbing the information flow of motor commands.

http://ping.fm/nyNfC

Parkinson’s Treatment Tips for Constipation

Constipation is an alteration in stool frequency, consistency, and/or passage of stool. The normal pattern of bowel movements can and will vary by 1 to 3 days. A stool-voiding pattern of every day or every other day is encouraged.

http://ping.fm/Fbkph

Fall is the season for apples

A variety of health benefits also comes in this tasty fruit. As early as medieval times, apples and products made from apples have been used for their health benefits. The saying, “An apple a day keeps the doctor away,” is the modern version of the old English saying.
Phytonutrients found in apples helps to protect the brain from age-related diseases, such as Alzheimer’s and Parkinson’s disease.

http://ping.fm/qnjRo

Exercycle Company's therapeutics exercise bike wins NIH grant

RSS Industries Inc., which does business as The Exercycle Company, has won a Small Business Innovation Research grant from the National Institutes of Health to develop powered exercise cycles as a treatment for Parkinson’s disease.

http://ping.fm/zsiic

Parkinson's sufferer Mike Allen to climb Kilimanjaro

A Sandhurst man who suffers from Parkinson’s disease is climbing Africa’s tallest mountain to raise cash for others suffering from the disease.

http://ping.fm/98Opn

Stem cell research used cloning technique, paid women for eggs

Scientists announced Wednesday that they had created stem cells from human clones, adding DNA from adult cells to the genetic material in unfertilized eggs. Their creation marked a first in stem cell research and may point the way toward treatments for diseases such as diabetes, Alzheimer's or Parkinson's.

http://ping.fm/qaoo2

HMC adopts music as tool for treatment

Studies are finding that music can have a variety of therapeutic effects. In 1995, researchers found that listening to Mozart before an IQ test boosts scores by roughly nine points. In another research, stroke victims and patients with Parkinson’s disease exposed to 30 minutes of rhythmic stimulation daily showed significant improvements in their ability to walk. A daily dose of Mozart given to chronically ill and depressed patients made them more cheerful, stable, and sociable. It has also been shown to boost the immune function in children. Premature babies exposed to lullabies in the hospital also went home earlier.

http://ping.fm/6ps3E

Diet in Early Stages of PD

In the early stages of Parkinson's disease (PD), no special dietary changes are typically required. You may want however to increase your intake of foods rich in antioxidants. Antioxidants are those chemicals that scavenge and eat-up so-called ‘free radicals’ –- tiny molecules that circulate in your tissues and damage those tissues. Free radicals have a special affinity for cells that produce dopamine. So the greater the number of antioxidants in your system, the fewer the number of circulating free radicals. Theoretically that should reduce the rate of loss of dopamine cells over time.

http://ping.fm/rQEE1

Exercise for People with Parkinson's Disease

Parkinson's disease (PD) is a neurological disorder that can have an effect on motor planning and can cause changes in movement control. Physical therapy treatment often centers on improving safe functional mobility and maintaining ease of movement in people with PD. Exercise is one facet of treatment that can help control symptoms of the disease and improve movement.

http://ping.fm/XGmCX

New test helps identify Parkinson’s disease

A new test is giving doctors and patients a clearer picture of Parkinson’s disease, and Parkinson’s syndrome. Nuclear medicine specialists at Orlando Regional Medical Center (ORMC) are now using DaTscan – the first Food and Drug Administration-approved imaging agent to help diagnose patients with suspected Parkinsonian syndromes, such as Parkinson’s disease — a neurodegenerative disorder that afflicts nearly 1.5 million Americans, with an additional 50,000 to 60,000 new cases identified each year. ORMC is the first hospital in Central Florida certified to perform the test.

http://ping.fm/BoOtV

Parkinson's Disease - New Finding

Small amounts of diseased brain proteins can be taken by healthy neurons and propagated within them to cause neurodegeneration, says study. This finding sheds light on the mechanism associated with Parkinson's disease (PD)and provides a model for discovering early intervention therapeutics that can prevent or slow the devastating loss of neurons that underlies PD.

http://ping.fm/Z8QFC

Early Parkinson's diagnosis aided by new technology

To diagnose Parkinson's disease, physicians for decades have had to rely largely on a keen eye and experience.
Now the pairing of a new drug and a high-tech nuclear brain scan is offering long-awaited help in recognizing the progressive movement disorder, which has neither a specific diagnostic test nor a cure.

http://ping.fm/a0emi

Physical Therapy Evaluation for Parkinson's Disease

If you have been diagnosed with Parkinson's disease (PD) your doctor may refer you to many specialists to help you move and function better. A physical therapist is a movement specialist who can assess and treat the motor control and planning changes that occur with the disease.


http://ping.fm/g2RiD

Caffeine's buzz chases away women's depression

Compared with uncaffeinated women, those who drank the equivalent of four or more cups of coffee a day are more likely to drink alcohol and smoke cigarettes and less likely to volunteer their time in church or community groups. But a new study finds that well-caffeinated women have a key health advantage over their more abstemious sisters: they’re less likely to become depressed.

http://ping.fm/V0v3I

Scientists take key step in stem cell therapy

For the first time, scientists have used cloning techniques — inserting genetic material from adult cells into unfertilized human eggs — to create embryonic stem cells.

http://ping.fm/Ajype

Essential Tremor vs. Parkinson’s Disease (ET vs. PD) - Differences & Similarities

Both Essential Tremor and Parkinson's Disease are common movement disorders that affect many people around the world. Tremor shakes can happen at rest, while holding objects, and can also effect the head and the vocal cords. Neither of these movement disorders can be diagnosed with blood tests or MRI/CT brain imaging technologies. However, brain scans can help determine the origin of some movement disorders.

http://ping.fm/j4J3u

Treating Parkinson's Disease

Although no cure has been created for Parkinson's disease yet, many treatment options are available for people with all different types of the disease.

http://ping.fm/RmokR

Parkinson's experimental gene therapy shows promise

As many as 60,000 Americans are diagnosed every year with Parkinson's Disease. Patients may have tremors, stiffness, and loss of motor control as the disease progresses. But a new study is showing experimental gene therapy may hold real promise for some patients.

http://ping.fm/iL5Kx

Nutrition for the Prevention of Parkinson's Disease

Parkinson's disease is a brain disorder that affects brain cells or neurons responsible for muscle movement. Symptoms of Parkinson's may include trembling hands, jaws, legs or fingers, slow movement and poor balance and coordination. Diet may play a role in preventing neurodegenerative diseases, such as Parkinson's.

http://ping.fm/udTfH

YouTube videos can inaccurately depict Parkinson’s disease and other movement disorders

Looking online for medical information? Viewers beware, doctors caution. After reviewing the most frequently watched YouTube videos about movement disorders, a group of neurologists found that the people in the videos often do not have a movement disorder. As described in a Letter to the Editor in this week’s New England Journal of Medicine, such medical misinformation may confuse patients suffering from devastating neurological disorders and seeking health information and advice online.

http://ping.fm/7skOx

Parkinson’s patient credits activity for crash recovery

Four months ago, Dan and Cathy Maxwell were involved in a devastating single-vehicle accident in Eastern Oregon.
Dan broke both bones in his lower right leg. His left ankle was shattered. His right shoulder was crushed. His face was torn open by shards of glass.
Cathy was pronounced dead at the scene, just one day before the couple’s 42nd wedding anniversary.
Doctors told Dan he wouldn’t walk for six months. But he had other plans.

http://ping.fm/Plhyt

Professors look to song to combat disease

While the feel-good effects of singing are well-documented, experts believe that joining a choir could improve the symptoms of a range of health problems including Parkinson's, depression and lung disease.

http://ping.fm/kbl5j

FDA Blocks Sale of Supplements for Parkinson's and Alzheimer's

The FDA filed a permanent injunction against two Minnesota companies that distributed amino acid products marketed as treatments for Parkinson's disease, Alzheimer's disease, and a number of other neurological disorders.

http://ping.fm/JIU1o

Children's Teeth Help Stem Cell Research

Experts say children's teeth might hold the key to effective treatments for diseases like Parkinson's disease and diabetes.

Children's teeth may be more valuable than a quarter under their pillow from the Tooth Fairy.

http://ping.fm/IBzaX

HEALING OF PARKINSON'S DISEASE THRU EXERCISE

Exercise plays a key role in the management of Parkinson's disease (PD). If done regularly, it may slow down the progression of the disease. It usually includes stretching, strength training and aerobic activities.

http://ping.fm/RJRSJ

Isotope Biomarkers Reveal Protein Fingerprints of Brain Disease

Rational and exploratory biomarker discovery approaches through putative linkage with pathways relevant to neurodegeneration; Real-time indices of neuronal dysfunction and reparative processes; Ability to measure dynamic biological and biochemical processes occurring in neurodegeneration and to move quickly from animal studies to human trials.

http://ping.fm/BeGbU

Coffee could offer key ingredient for new treatments for Parkinson's disease
Caffeine is a methylxanthine, a stimulant derivative of xanthine, as is theophylline (in tea), and theobromine (in chocolate). Methylxanthines are among the most widely consumed substances in the world. Caffeine is present in many foods and drinks and reportedly consumed at an average rate of 200mg per day by Americans (Ref. 1). In 2000, the Journal of the American Medical Association(JAMA) published research showing a correlation between higher intake of caffeine and lower incidence of Parkinson’s disease, a devastating and incurable neurological disorder.

http://ping.fm/2C4xc

The Best Diet to Alleviate Insomnia in Parkinson's Patients

Common signs and symptoms associated with Parkinson's disease include tremors, lack of facial expression, muscle aches and constipation. Insomnia, notes a 2007 study by M.D. Gjerstad and colleagues published in the "Journal of Neurology, Neurosurgery and Psychiatry," is a common complaint among people with Parkinson's disease, varies in severity over time and may be caused by numerous factors. Many people who have Parkinson's disease-related insomnia may also be depressed, note the researchers.

http://ping.fm/yZJfa

The ‘DRUMS ALIVE’ exercise
Research said drumming improves and increases the neurological connection between right and left brain hemispheres, releases tension, and eases stress. The synchronization of both brain hemispheres stimulates Alfa Brain Wave activity, which leads to higher levels of concentration, enhanced sensory and motor coordination, and an improved overall sense of well-being.

http://ping.fm/8aKuc

Parkinson's disease cant diminish their song

Fed up with her voice weakening because of Parkinson’s, 65-year-old Mags Blackwell decided to sing about it.
Part spirit-lifter, part exercise, part scientific experiment, the singing group Blackwell formed with a friend at Lee First Congregational Church works to mollify what one woman called an "invasive, elusive" disease.

http://ping.fm/BL7QM

Scientists Discover Genetic Mutation That Causes Parkinson's Disease

A large team of international researchers have identified a new genetic cause of inherited Parkinson's disease that they say may be related to the inability of brain cells to handle biological stress.

http://ping.fm/rmEYx

Protein Linked to Parkinson's Disease May Regulate Fat Metabolism

National Institutes of Health researchers have found that Parkin, an important protein linked with some cases of early-onset Parkinson's disease, regulates how cells in our bodies take up and process dietary fats.

http://ping.fm/JQzRK

Researchers enlist symptom-specific exercise in battle against Parkinson's Disease
The benefits of exercise training for people with Parkinson’s disease are well established and have been a theme during the eight-year history of the Sunflower Revolution

http://ping.fm/gtQiS

New Imaging Test Gives Physicians Better Tool to Diagnose Parkinson's Disease
Thanks to a new diagnostic imaging technique, physicians now have an objective test to evaluate patients for Parkinsonian syndromes, such as Parkinson's disease.
http://ping.fm/m4eUq

Exercise for PD: More Fun Water Activities to Try Before the Summer Ends!
Working out in the water can be very beneficial if you have Parkinson's disease (PD), says the American Parkinson's Disease Association. Having PD can affect your gait and make walking challenging. You may tend to hold your arms stiff as you walk and take quick, short shuffling steps. To help combat this, try water walking.

http://ping.fm/YivV9

Breakthrough in Stem Cell Growth Measures
Scientists in Scotland experienced a significant breakthrough in Parkinson's disease research this week when researchers reported successfully growing stem cells from the skin of a patient with a rapidly progressing form of the disease.

http://ping.fm/vhuvt

Protein Intake and PD Medication Absorption
Patients with Parkinson's disease commonly experience a general slowing of the digestive system, which can affect the efficiency of nutrient absorption. Recently, we wrote about the absorption benefits of timed meal plans. Timing your protein intake is an especially important aspect.
http://ping.fm/SRMkT

Visual and Auditory Cues Help PD Patients Walk with Confidence

For PD patients, relaxed walking may be a luxury long forgotten. However, advances in the field of neurological rehabilitation recently revealed wonders of the human mind. By interacting with the external environment, and utilizing a few tricks internally, PD patients can make great strides in retaining motor skills.

Visual and auditory cues are used in rehabilitation to help individuals diagnosed with PD improve their walking movements. Visual cues include parallel lines on the ground, used as a guide for stepping. Auditory cues like high-pitched and low-pitched notes can be executed internally to remind one when to take steps.

Do you have any visual or auditory cues that have brought you success?

http://ping.fm/MkZkO

New Culture Method May Give Stem Cell Therapy a Boost

Parkinson’s patients are only one of several groups to benefit from an important new discovery in the world of stem cell therapy. Scientists at the University of Glasgow in Scotland have uncovered a new method for culturing adult stem cells.

Created by an injection-moulding process similar to the method used to produce Blu-ray discs, this new plastic culture medium could yield a large enough batch of stem cells to kick-start the process of cellular regeneration.

Dr. Matthew Dalby, from the University of Glasgow, said, "Our technology could be the first step on the road to developing large-scale stem cell culture factories which would allow for the creation of a wide range of therapies for many common diseases such as diabetes, arthritis, Alzheimer's disease and Parkinson's disease."

Visit our website to learn more about this exciting new stem cell culture method!

http://ping.fm/a5STR

Check out our new home page with interactive features. You asked and we listened. http://ping.fm/ENF8l

To Ease PD Symptoms, Try Walking in Water
Symptoms of Parkinson’s disease can affect your gait making a difficult task out of even a short walk. You may begin to take quick, short shuffling steps and stiffen your arms as you walk.
How can you regain your relaxed stride? Try water walking.
http://ping.fm/2Up9J

Scientists have only just begun to conclusively prove a genetic predisposition to Parkinson’s disease, lying to rest former theories that environmental factors such as exposure to chemicals were solely to blame.
http://ping.fm/mrnyX

Consider This: The Nuances of Treating PD
Laxatives
Long-term laxative use can reduce your absorption rate of nutrients and dietary supplements, which may lead to increased consumption requirements of certain nutrients in order to absorb the amount you really need.
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According to a small study conducted by Canadian researchers, the benefits of deep brain stimulation (DBS) in controlling tremors and improving motor function for those with Parkinson's disease appears to last at least 10 years.

http://ping.fm/zZXZe

Sam Fox’s Herculean Effort to Raise Parkinson Awareness

A new documentary in the works will chronicle one runner’s upcoming attempt to break the world record time for crossing the grueling 2650-mile Pacific Crest Trail, but that’s only the beginning. For nearly half his life, distance athlete Sam Fox has watched his mother battle Parkinson’s disease.

http://ping.fm/04qPO

Rapid Eye Movement (REM) Sleep Behavior Disorder Linked to Increased Risk of Developing Parkinson’s Disease

Studies published in the scientific journal Lancet Neurology report that a Rapid Eye Movement (REM) sleep behavior disorder (RBD) diagnosis can be linked to an increased risk of developing Parkinson's disease (PD).

http://ping.fm/PqRDD

Magnesium and PD
A study published in the international scientific journal "Neurotoxicology," measured the levels of two chemicals in the brain and found that Parkinson's patients have higher levels of aluminum and lower levels of magnesium than the control group participants.

http://ping.fm/UMOtB

Parkinson disease (PD) patients: Trouble sleeping? Tell Your Neurologist!
PD patients often complain of sleep troubles, and a new article published by Columbia University encourages patients to address the issue. An important feature of PD, sleep disturbances deserve clinical attention.

If you have PD and have trouble sleeping, keep a detailed history of your specific sleep problems, such as: excessive daytime sedation, difficulties with sleep onset, frequent awakenings, increased movements during sleep, acting out dreams, and abnormal breathing.

The more information you provide your PD clinician, the more successful your sleep therapy treatment will be!

http://ping.fm/QCrC4

Annual PD Awareness Concert Event in Geneva, Illinois

The Paul Ruby Foundation for Parkinson’s Research will host its annual event, Concert for a Cure, on Saturday August 27th at the Tanna Farms in Geneva, Illinois. Concert for a Cure is an afternoon of family friendly music featuring local bands from the greater Chicago area. Join the Paul Ruby Foundation for a Parkinson’s awareness event full of fun for the whole family!

http://ping.fm/vSFPr

Why Does Dance Therapy Work So Well for Parkinson Patients?

In her academic paper “Dance as Therapy for Individuals with Parkinson Disease,” published in the “European Journal of Physical and Rehabilitation Medicine,” Gammon M. Earhart, an Associate Professor of Physical Therapy at Washington University’s School of Medicine, finds that Parkinson’s disease patients have much to gain in a dance program.

http://ping.fm/Onx6T

SHARE YOUR STORY: Clinical Trials

When diagnosed with a disease not yet curable, patients, caregivers and loved ones are faced with a colossal decision: whether or not to participate in experimental treatments and clinical trials.

http://ping.fm/XqusY

CoQ10: Larger Studies Still Needed
Researchers continue to explore the efficacy of Co-Enzyme Q10 (CoQ10) in aiding Parkinson’s treatments. Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells.

http://ping.fm/I2vdn

CoQ10: Larger Studies Still Needed
Researchers continue to explore the efficacy of Co-Enzyme Q10 (CoQ10) in aiding Parkinson’s treatments. Coenzyme Q10 (CoQ10) is produced by the human body and is necessary for the basic functioning of cells.

CoQ10 levels are reported to decrease with age. In many patients with chronic diseases, including PD, low levels of CoQ10 are often reported. Supplemental forms of CoQ10 are available by traditional vitamin distributors, and can even be found at the grocery store.

Unfortunately, research has yet to confirm whether taking CoQ10 as a supplement offers any relief from PD. Larger studies with human subjects are still needed to offer conclusive evidence either way.

What are your thoughts on CoQ10? Do you take the supplement?


http://ping.fm/VpciQ

Cannabis as a Treatment for PD?
According to a new study published in the scientific journal British Journal of Pharmacology, cannabis’ active components show promise in slowing the progression of Parkinson’s symptoms .

An international team of researchers from Spain and Israel assessed the potential of cannabinoids to slow the progression of both Huntington’s disease (HD) and Parkinson’s disease (PD), both of which are considered inadequately managed by conventional treatment therapies.

Researchers noted that both THC and cannabidiol (CBD) were observed to “protect nigral or striatal neurons in experimental models of both disorders.” Investigators added that the separate “activation of CB(2) [cannabinoid] receptors leads to a slower progression of neurodegeneration in both disorders.”

Authors concluded, “Evidence reported so far supports that those cannabinoids having antioxidant properties and/or capability to activate CB(2) receptors may represent promising therapeutic agents in HD and PD, thus deserving a prompt clinical evaluation.”

http://ping.fm/mVhOb

Drug Concerns for Parkinson’s Patients

According to an article recently published in the Wall Street Journal, powerful anti-psychotic drugs are routinely prescribed to elderly people with Parkinson's disease, despite warnings about the associated risks of using this type of medication when treating aging populations.
Most well known for affecting motor function, symptoms of Parkinson’s disease extend past the physical realm. Documented occurrences of psychological disturbances are often reported in patients during the later stages of PD, compounding the typical changes that occur in the aging mind.
There are currently no PD-specific anti-psychotic drugs, leaving doctors with a guessing game as to which drugs best treat Parkinson-induced psychotic symptoms. Many doctors are turning to a family of drugs with approved uses for schizophrenia and other psychotic conditions; drugs which contain little or no clinical basis for efficacy in treating PD symptoms.
The article urges clinicians to become more educated on what they are prescribing, but stresses that it is ultimately up to the patient and caregiver to be passionately engaged in their care.

http://ping.fm/Oeppa

Drug Concerns for Parkinson’s Patients

According to an article recently published in the Wall Street Journal, powerful anti-psychotic drugs are routinely prescribed to elderly people with Parkinson's disease, despite warnings about the associated risks of using this type of medication when treating aging populations.
Most well known for affecting motor function, symptoms of Parkinson’s disease extend past the physical realm. Documented occurrences of psychological disturbances are often reported in patients during the later stages of PD, compounding the typical changes that occur in the aging mind.
There are currently no PD-specific anti-psychotic drugs, leaving doctors with a guessing game as to which drugs best treat Parkinson-induced psychotic symptoms. Many doctors are turning to a family of drugs with approved uses for schizophrenia and other psychotic conditions; drugs which contain little or no clinical basis for efficacy in treating PD symptoms.
The article urges clinicians to become more educated on what they are prescribing, but stresses that it is ultimately up to the patient and caregiver to be passionately engaged in their care.

http://ping.fm/WMKnd

SHARE YOUR STORY: Exercise
The National Institute of Health has funded numerous studies that yielded findings supportive of the claim that exercise is a useful adjunct therapy for individuals diagnosed with Parkinson’s disease.

Do YOU have a regular exercise program?

What exercises have helped you the most?

New Research Reports Some Welders Develop Symptoms with a Parkinson’s Resemblance

Published in the medical journal Neurology, new research finds an increased incidence of mild movement disorder symptoms in career welders. Compared to non-welders, welders had an 11.7 percent reduction in a dopamine marker. Due to the small size of the study (only 60 participants total) more research is needed.

Welders are often exposed to manganese, a trace mineral that past research has linked to neurological disorders, including Parkinson's disease.

Study authors stress that the motor deficiencies observed in the welder study subjects are not demonstrative of classic Parkinson’s disease, but more of an off-shoot presumably resulting from dopamine deficiency.

http://ping.fm/1asEj

One More Cup of Coffee


Coffee staves off PD? A new AMA study says yes, but can’t say specifically why.

A recent study published in the Journal of the American Medical Association found 3-5 times less incidences of PD in coffee drinkers (who drank approx. five cups a day) than in non-coffee drinkers.

While this prognosis was originally attributed to coffee’s caffeine content, studies were unable to replicate these results by administering other sources of caffeine.

The jury is still out as to why coffee may stave off Parkinson's.

http://ping.fm/LKyvd

Title: Bob Dylan
Image: www.fanpop.com

New Rodent Model Study May Offer Clues to Alternative Treatments for PD

Few treatments for Parkinson's disease (PD) restore function for extended periods of time. A new study published in the inaugural issue of Journal of Parkinson's Disease, found that platelet-derived growth factor-BB (PDGF-BB) therapy restored long-term functional improvements in experimental models of Parkinson's disease in rodents.

An international group of researchers reported that an infusion of PDGF-BB counteracted classic PD behavioral, tissue and biochemical changes.

Study authors concluded that PDGF-BB shows promise as a clinical candidate drug for the treatment of PD in humans.

http://ping.fm/ke10M

Lithium Protects the PD-Brain?

A recent study from the Buck Institute for Research on Aging in California found that the drug lithium greatly prevented the buildup of toxic proteins and brain cell loss linked to Parkinson's disease. The results, found using laboratory mice, were published in last month’s issue of the Journal of Neuroscience Research.

Previous animal studies have also demonstrated lithium’s neuroprotective effect in regards to Huntington's disease, and Alzheimer's disease. Investigators at the Buck Institute for Research on Aging have started preclinical studies to determine the proper lithium dosage for humans, and hope to soon initiate Phase II clinical trials in conjunction with Parkinson's disease.


http://ping.fm/85KJN

Can Motorized Stationary Cycling Provide the Same Tested Benefits as Cleveland Clinic’s Forced Tandem Cycling Trials?
Dr. Jay Alberts of the Cleveland Clinic, made famous by his research linking the tandem cycling’s positive effects on those with Parkinson’s, is at it again – this time, testing motorized stationary bicycles.

Alberts original clinical trials discovered that stationary tandem riding with the patient in the back and a trainer in the front forces Parkinson patients to ride faster than they normally would, which challenges the body and the brain. Alberts says this releases dopamine and activates the part of the brain that controls body movement, which may explain the improvement in symptoms.

His new research, which he began in June 2011, will seek to discern whether motorized stationary cycling can produce the same reduction in PD symptoms as his original study.



http://ping.fm/K2ly3

New Research Suggests Stem Cells Delivered Intranasally Improve Motor Function in Parkinson’s Disease

Using a rat model of Parkinson’s disease, new research published in the journal Rejuvenation Research demonstrated that stem cells delivered intranasally survived for at least six months in the brain, that the stem cells rapidly migrated preferentially to the damaged areas of the brain, and that motor control showed significant improvement.

Researchers theorized this likely occurred because of the demonstrated anti-inflammatory and neuroprotective effects of the stem cells, which were derived from bone marrow.

Study authors concluded that intranasal administration of stem cells to the human brain is a promising and noninvasive alternative to current surgical procedures. It also opens up the possibility of chronic stem cells treatment, which would increase the number of cells delivered to the brain and likely enhance the therapeutic benefit.

This research was funded by the Alzheimer’s Research Center, a nationally recognized research hub conducting studies on Alzheimer’s, Parkinson’s disease, and other neurodegenerative disorders.


http://ping.fm/oE5XK

Fluids and Fiber
Seeking advice on how nutrition may help manage PD symptoms? Consult a clinical nutritionist for guidance on planning meals that provide enough fluids and fiber.
Both will help reduce constipation and dehydration, and may minimize other harmful gastro-intestinal complications associated with the disease. As always, consult your healthcare provider before making any changes to your treatment regimen, including dietary alterations.

http://ping.fm/Ne17M

Conquering Cruise Phobias
When I was a non-cruiser, I never thought I would like cruising. I was fearful of being confined, cooped up, and claustrophobic. I was worried about getting seasick. I longed for an active vacation of riding bicycles and hiking mountains. I didn’t want to get fat eating meals round-the clock. I dreaded being around all those old people.
http://ping.fm/BnZ7i

SHARE YOUR STORY:
Deep Brain Stimulation Surgery (DBS)

According to the National Institute of Neurological Disorders and Stroke, deep brain stimulation (DBS) is a surgical procedure used to treat a variety of disabling neurological symptoms—most commonly the debilitating symptoms of Parkinson’s disease (PD). At present, the procedure is used only for patients whose symptoms cannot be adequately controlled with medications.

Have you undergone DBS? Share your experience!

For example did you experience anything unexpected? What advice would you give fellow PD patients considering DBS?

Recent Role Gives Hollywood Actress Anne Hathaway New Perspective on Parkinson’s Disease


In the 2010 film “Love & Other Drugs,” Anne Hathaway stars as an early-onset Parkinson’s disease (PD) patient with an “everyday could be your last” mentality that often prompts her to live on the wild side. In preparing for the role, Hathaway said she spent considerable time researching PD, including attending Parkinson’s support groups.

What she learned:

“They shared their stories with me …their fears and anxieties but also their triumphs. I learned that Stage 1 Parkinson’s is all about good days and bad days,” said Hathaway.



http://ping.fm/g0xmL

Do You Practice Tai-Chi?


A new review of 35 studies assessing the health effects of tai chi confirm that the ancient Chinese martial art form helps reduce the risk of falls in seniors and also improves their mental health.
Do you practice tai chi as a supplemental therapy for Parkinson symptoms?

http://ping.fm/rKqDe

photo: US Department of Energy

University of Colorado Researchers Study Promising Parkinson’s Drug, Yield Encouraging Results

Colorado researchers have discovered a drug that stops the progression of Parkinson's disease in mice and is now being tested on humans.

The research team found that the drug phenylbutyrate turns on the DJ-1 gene, which can protect dopamine neurons in Parkinson's disease. They found that phenylbutyrate works on DJ-1 in a way similar to how steroids act on genes in muscle cells to create muscle bulk.

Researchers plan to study phenylbutyrate further and hope to expand the study to hundreds of people over several years.

http://ping.fm/KDEvs

Eat on Time!



PD often affects the digestive system, leaving individuals nauseous and without a healthy appetite.

How can you ensure optimal digestive function and proper absorption of your PD-medications?

One vital strategy is to maintain a regular meal schedule.

Ask your doctor to recommend a clinical nutritionist who can help you create a meal plan catered to your medications, your schedule, and your medical history.

http://ping.fm/tCekM

Image: www.Dreamstime.com

Scientists Explain Paradoxical Effect of Dopamine Replacement Therapy on Cognitive Function

The scientific journal Brain: A Journal of Neurology recently published the results of a revolutionary study out of Montreal that may explain the Catch-22 of dopamine replacement therapies (DRT) used to treat Parkinson’s disease. While DRT improves cognitive function in one area of the brain, it is at the expense of another.

The study’s lead author, Oury Monchi, Ph.D. explains:

“When it comes to [PD], the part of the brain most affected by dopamine depletion is the striatum which is divided into several structures. In PD, the dorsal striatum is more severely affected than the ventral striatum, which remains relatively unaffected, at least during the first phases of the disease. We observed that while dopamine replacement therapy enhances the functions of the dorsal striatum, it is at the expense of the ventral striatum which suffers a dopamine overdose, impairing its function.”

http://ping.fm/h8jth

CASE STUDY: Former Physician Mac Stinson Diagnosed with Parkinson’s Finds Success Using Intestinal Drug Delivery System

Powerful testimonial from Mac Stinson demonstrates one Parkinson disease (PD) patient’s personal success using a new delivery method to receive his PD medications. The drug is delivered via a pump to the small intestine; the latest advance is a gel that encapsulates the medication as it travels through the pump, allowing the medication to arrive virtually unaffected by water.

Mac Stinson is currently participating in a clinical trial of the gel/pump system and reports a significant drop in symptoms since beginning the new delivery system. A retired physician, Stinson says he is so happy to resume his jazz guitar playing and church choir singing.



http://ping.fm/2m2Tx

CASE STUDY: Jane Busch Turns to Latin Dance to Help Ease Parkinson Symptoms

Jane Busch, a retired dentist from Cross Plains, Wisconsin, turns to Zumba, a form of Latin dance, not only to keep herself fit and active, but also to combat the deterioration of motor skills that accompanies Parkinson’s disease.

http://ping.fm/3N1cJ

Ask the Worms!
A new discovery may just revolutionize the path of Parkinson disease (PD) research…and it all thanks to tiny worms!
Scientists at McMaster University in Ontario have just discovered that nemotodes, tiny worms barely visible to the human eye, share genetic similarities to the human brain’s dopamine neurons that are affected by Parkinson’s.

http://ping.fm/hEwSJ

Zinc and PD
Researchers from the Department of Human Genetics at the University of Michigan (UM) recently studied 30 Parkinson’s disease (PD) patients and found an interesting similarity among them: zinc deficiency.

UM researchers discovered that the subjects with PD had markedly less zinc in their blood than those in the control group.

http://ping.fm/htIjk

NOW ENROLLING: New Global Study Investigates Medication Designed to Treat Early-Stage Parkinson’s

A new study testing CoganeTM (PYM50028) - a medication designed to treat early-stage Parkinson’s disease – just moved into Phase II clinical trials. United Kingdom researchers are currently recruiting 400 participants worldwide.

Eligible participants are men and women between ages 35 and 75 with a diagnosis of Parkinson’s within the last two years. The research will study whether Cogane could slow down or modify the progression of Parkinson’s. Cogane is a new compound that modulates proteins in the brain that help the survival, development and function of nerve cells.

For more information, see Clinical Trials: Studies Seeking Participants.

http://ping.fm/rQWPp

Exercise Your Voice!
With exercise becoming an ever-present supplemental treatment for PD symptoms, let’s not forget to exercise our voice!

Check out our very own Mary Sprumelli as she guides us through several vocal exercises designed specifically for PD patients!

http://ping.fm/bH48Z

NOW ENROLLING: New Study To Investigate Novel Apathy Intervention Treatments
While motor dysfunction is most apparent in PD, patients also exhibit many non-motor symptoms, one of the most prevalent being apathy. Neuropsychiatric literature describes apathy as a reduction in self-initiation and motivation. Elevated apathy has been associated with reduced treatment compliance, poor illness outcome, and reduced quality of life.

http://ping.fm/1mwMq

Solutions for PD-associated Nausea
Levodopa, the leading PD pharmaceutical, often causes nausea when taken on an empty stomach. Nausea is an uneasiness of the stomach that often accompanies the urge to vomit, but doesn't always lead to vomiting. If nausea is a continual problem, please consult your doctor.
http://ping.fm/9Q726

Ibuprofen May Protect Against Parkinson’s Disease

A new study published in the medical journal Neurology suggests ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), may offer protective benefits against developing Parkinson’s disease (PD).

http://ping.fm/1IGKv

Zinc Deficiency and Parkinson's.Recent research has demonstrated a link between a lack of zinc in the diet and Parkinson's disease onset. http://ping.fm/yhCSt

Tandem Bicycle Exercise for Parkinson's Disease. When you think of Parkinson's disease, you probably don't think of patients riding a bicycle built for two, also known as a tandem. However, doctors at the Cleveland Clinic found that the exercise can help relieve the symptoms of Parkinson's disease.http://ping.fm/vV3gy

Weekly Zumba class helps Parkinson's sufferers keep their muscles and memories sharp. Fight fire with fire, or so they say, and that’s the approach Jane Busch takes in her ongoing battle against Parkinson’s disease. To fight the effects of the condition that slowly robs sufferers of the ability to move, Busch moves — a lot.
http://ping.fm/7a1Hd

PARKINSON'S DISEASE: DETECTING PARKINSON’S DISEASE WHEN IT MIGHT STILL BE CURABLE.A patient with Parkinson’s disease (PD) has to lose 60-70% of the nerve cells in a particular area of the brain before the physical symptoms of PD appear. http://www.parkinsonresearchfoundation.org/resources/information.aspx?post=8cfbb238-b02e-4b80-b938-51d86400ee65

Exciting new Parkinson’s research in Canada.
Recruitment is underway in Quebec City, Gatineau, Ottawa, London, Saskatoon and Edmonton, for 60 men and women between 35 and 75 years old who have been diagnosed with Parkinson’s within the last two years, to participate in a phase II clinical trial to test the efficacy, safety and tolerability of CoganeTM (PYM50028) in treating early-stage Parkinson’s.http://ping.fm/BK6gg

Could Tibetan Terriers hold a key to treating PD in humans?

The same gene mutation that causes a fatal neurological disease in Tibetan Terrier dogs also causes a hereditary form of Parkinson's disease in humans, a new study reports.

Please support our foundation by submitting a review of our foundation on http://ping.fm/6XGYi

The Benefits of All That Hard Work!
You’ve heard how beneficial a regular exercise routine can be for those with Parkinson’s, but what exactly do you seek to gain?

http://ping.fm/zKJu5

New Parkinson Treatment Program Explores the Benefits of Ballet

According to a recent 12-week project sponsored by the English National Opera, ballet-inspired dance therapy may ease the symptoms of Parkinson’s disease.

http://ping.fm/EtdUC

Creatine for Parkinson’s Disease?
In 2007, scientists at Rush University Medical Center began conducting a clinical trial to determine whether taking a creatine supplement can slow the progression of PD. The study is still in developing, as scientists assert it requires several years of observation to accurately determine creatine's effect on disease progression. Results are expected sometime in 2012.

http://ping.fm/YAcWA

New Hope for Long-Term Treatment of Parkinson’s Disease

Few treatments for Parkinson's disease (PD) restore function for any extensive period of time. In a new study published in the premiere issue of the Journal of Parkinson's Disease, an international group of researchers report that platelet-derived growth factor-BB (PDGF-BB) restored function in rodents and shows promise as a clinical candidate drug for treatment of Parkinson’s disease.

http://ping.fm/TxBsP

New Study Suggests “Friendly Fire” As Possible Cause of Parkinson’s Disease

A team of researchers from the University of Florida published a new study suggesting that the pathway located at the base of the brain that is essential for the execution of smooth, coordinated movements may be selectively damaged by the friendly fire of the body’s immune response.

http://ping.fm/nl4Pn

Researchers release specific exercise recommendations designed to protect against falls.
Physicians in Otago, New Zealand, discovered that a regular combination of strength and balance exercises significantly reduced falls in those who are 65 and older. The recommended exercise program consists of progressive resistance and balance training done three times a week and walking with supervision for 30 minutes twice a week.

http://ping.fm/u8bkU

Melanoma and Parkinson’s Disease?
New data analysis suggests Parkinson’s disease patients have double the risk of developing the skin cancer melanoma.
http://ping.fm/0fi7k

Could what you eat influence dopamine levels? Researchers attempt to find out what connection if any, can be made between diet and dopamine production.
New research is uncovering the efficacy of dietary nutritional compounds as modulators of the dopaminergic system, with the hopes that certain foods may supplement the dopamine-producing effects of Levodopa.

http://ping.fm/MTjCd

Keeping Neurons Alive!
An upcoming clinical trial will attempt to solve problems that have plagued one potentially promising Parkinson’s disease (PD) treatment.

A pending clinical trial has researchers at University of California San Francisco (UCSF) hopeful about evolving the treatment of Parkinson’s disease. If the study receives final FDA-approval, human subjects will receive experimental gene therapy using glial-derived neurotrophic factor (GDNF), a protein that helps keep neurons alive.

http://ping.fm/tn5uc

Sleep Watchers
The University of Sydney’s Brain and Mind Research Institute observe patients’ sleep patterns with hopes of finding clues to the possible causes of Parkinson’s disease (PD).
Lewis’ conducts research that monitors Parkinson patients’ sleep cycles in hopes to reveal more clues as to how PD manifests itself in the brain.


http://ping.fm/9ewg2

PARKINSON RESEARCH FOUNDATION
ANNOUNCES ROUTE FOR 2011 PEDALING FOR PARKINSON’S EVENT
On Saturday June 25, 2011, a team of cyclists led by Parkinson Research Foundation (PRF) Executive Director Brian Curro will embark on the second annual “Pedaling for Parkinson’s” ride, a 150-mile bicycle ride across the state of Florida to raise awareness of Parkinson’s disease.
http://ping.fm/NGeAJ

Exercise for Balance

Keeping a strong sense of balance is important for everyone as we age, but it is especially important for those with Parkinson’s disease.

According to an article published in the British Medical Journal in 2009:
68% people with Parkinson’s will fall
65% of fallers will experience an injury secondary to their falls,
33% will suffer a fracture
75% of falls will lead to use of a health care service
http://parkinsonresearchfoundation.org/resources/information.aspx?post=5b856317-f5a6-4928-8fbf-3025a42cfa28

Gene Injections Could Ease Parkinson’s Symptoms, New Trials Suggests
Scientists at biotech firm Oxford BioMedica recently completed initial trials testing the effectiveness of gene jabs as a treatment for Parkinson’s disease (PD). PD patients who received an injection of genes into the brain experienced a significant reduction of Parkinson’s symptoms.
http://ping.fm/MZ7vR

Two Pesticides Linked to Parkinson’s, New Study Suggests

In a study conducted by the National Institute of Health, researchers show a link between Parkinson’s disease and the use of two pesticides, rotenone and paraquat, both of which have no registered uses in home, garden, or residential environments.

http://ping.fm/FP6J3

CASE STUDY: Electroconvulsive Therapy (ECT) Administered to Patient with Parkinson’s and Clinical Depression

Depression often accompanies, and complicates Parkinson’s disease. Although electroconvulsive therapy (ECT) is an accepted treatment for depression, using ECT to treat Parkinson symptoms is not allowed in the United States.

http://ping.fm/jwQog

10 Early Signs of Parkinson’s Disease That Doctors Often Miss
A diagnosis of Parkinson’s disease (PD) is extremely difficult to endure, let alone seek out. However, diagnosing Parkinson’s in its early stages may add years of health and mobility to one’s life

http://ping.fm/UCW8g

PARKINSON RESEARCH FOUNDATION’S
PEDALING FOR PARKINSON’S EVENT
BRINGS AWARENESS TO THE
SCIENTIFICALLY PROVEN POSITIVE EFFECTS
PD PATIENTS STAND TO GAIN FROM CYCLING
http://ping.fm/80JnI

New Research Suggests Ulcer-causing Bacteria May Contribute to Development of Parkinson’s Disease

A new study using mice demonstrated more links between Parkinson’s and Helicobacter pylori (H. pylori), a common bacterium that may lead to ulcers and stomach cancers. Louisiana State University researchers presented the study at an annual microbiology meeting.

http://ping.fm/8Qscr

The Best Fruits and Vegetables for Parkinson’s Patients
Increasing your fruit and veggie intake is a good idea for anyone, especially those diagnosed with Parkinson’s. What fruits and veggies are most beneficial to Parkinson patients?

http://ping.fm/B93RL

Natural food pigment proves useful in treating PD
Curcumin, derived from the curry spice turmeric, reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model

Curcumin, derived from the curry spice turmeric, has strong antioxidant and anti-inflammatory properties. Both oxidative damage - damage caused by oxygen - and inflammation have been implicated in nerve cell death associated with Parkinson's disease.

http://ping.fm/Id2sq

Dance Your Way to Better Health!
New study seeks to measure the benefits of dance for individuals with Parkinson’s disease.

The University of Hertfordshire will begin two studies in June to evaluate the effects of various dance programs as therapy for Parkinson patients.
http://ping.fm/RH83n

New Research Aimed at Earlier Diagnosis of Parkinson’s Disease

An international team of researchers from Lithuania, Russia and Sweden, investigated how a simple blood test that measures antibodies could lead to early diagnosis treatments for several neurological diseases, including Parkinson’s disease.

http://ping.fm/aCPRj

Dance Your Way to Better Health! New study seeks to measure the benefits of dance for individuals with Parkinson’s disease. http://ping.fm/75sUe

New Research Aimed at Earlier Diagnosis of Parkinson’s Disease.An international team of researchers from Lithuania, Russia and Sweden, investigated how a simple blood test that measures antibodies could lead to early diagnosis treatments for several neurological diseases, including Parkinson’s disease. http://ping.fm/zS8gl

The Healthiest Color You’re Not Eating. The power of purple: Naturally purple foods have been linked to everything from memory protection to heart health. http://ping.fm/tnOEq

Placebo Effect More Powerful than Ever. A study in Vancouver proves the power of the placebo effect in Parkinson patients. Patients who were told they had a 75-percent chance of receiving active medication demonstrated a significant release of dopamine in response to the placebo, whereas those in the other groups did not. http://ping.fm/S6z17

To Study PD “Freezing”, Researchers Take the Brain on a Virtual Stroll. Scientists at the University of Sydney's Brain and Mind Research Institute are taking brains on a virtual stroll to learn more about the Freezing of Gait (FOG) phenomenon experienced by Parkinson patients. http://ping.fm/xAQmc

After Exercise, Mice with Movement-Disorder Symptoms Begin Producing Small Amounts Of Dopamine. Exercise is essential for the management of Parkinson's disease. A new British analysis evaluates the results of several research studies in the UK and affirms that movement disorder patients seek to gain many positive effects by participating in a structured exercise regimen. http://ping.fm/IYH3h

Urban Area Pollution Linked to Increased Risk of Developing Parkinson’s. According to a study by the Washington University School of Medicine in St. Louis, high levels of manganese and copper pollution in urban areas are linked to increased risk of Parkinson's disease. http://ping.fm/JDIde

Help Control Constipation with Proper Nutrition. Diagnosed with Parkinson’s and having less than three bowel movements a week? You’re not alone. Constipation is a common complaint from Parkinson patients. http://ping.fm/rgFnU

5-HTP and Parkinson’s. 5-HTP is the happy stuff: it’s one of the raw materials your body needs to make the neurotransmitter serotonin, a key factor in regulating mood, appetite and sleep cycles. http://ping.fm/Plakv

New Study of Denmark Population Links Midlife-onset Diabetes Diagnosis and Treatment with an Increased Risk of Developing Parkinson’s Disease. Researchers in Denmark used Danish Hospital Register medical records to evaluate the commonality of treatment for both diabetes and Parkinson’s disease. http://ping.fm/Fabnc

Omega-3 fatty acids may offer protection against Parkinson’s
Long celebrated as a super-food for the brain, omega-3 fatty acids find another fan in Parkinson researchers. http://ping.fm/CY9XM

Stop Smoking to Save Eyesight
Tobacco smokers are two to three times as likely to develop AMD, according to multiple scientific studies published by the AMD Alliance International. http://ping.fm/vndRu

Treating Parkinson’s Instead of its Symptoms
A Major Breakthrough with Mice could lead to Revolutionary Changes in the Treatment of Parkinson’s
http://ping.fm/ZmDj2

New Study of Denmark Population Links Midlife-onset Diabetes Diagnosis and Treatment with an Increased Risk of Developing Parkinson’s Disease
Researchers in Denmark used Danish Hospital Register medical records to evaluate the commonality of treatment for both diabetes and Parkinson’s disease. http://ping.fm/a9jGH

Announcing Next Educational Cruise for Parkinson's disease

We have announced our next Educational Cruise is set to sail January 8th-15th, 2012. What is it about a PRF cruise that makes it so much FUN? The social activities, exotic locales, educational, and interactive activities.

There's no denying it: Parkinson's patients sure know how to have a good time!With "What a Fun Way to Learn" as our cruise program slogan, we make sure cruisers receive ample opportunity to dress up, chow down, and dance the night away!

Ask yourself: When else will you be sailing the open sea with a boat full of Parkinson experts? PRF employs renowned neurologists and movement-disorder specialists to educate cruisers on revolutionary breakthroughs in Parkinson treatment research.

Ever wanted to try Tai-Chi? What about Yoga, armchair bootcamp or dance therapy? PRF diligently seeks out passionate movement-disorder therapists with innovative programs designed to help reduce Parkinson symptoms. These interactive sessions and daily support groups help our cruisers form special bonds.

Come cruise with us! For more information, please visit us on the web at http://www.parkinsonresearchfoundation.org/ or call (941)870-4438 We hope to see you on board! Thank you for your continued support.

Two Pharmaceutical Companies Join Forces to Develop Innovative Parkinson's Therapy!

Recently Medtronic, along with the Department of Veteran Affairs and the National Institute of Neurological Disorders, funded the largest clinical trial ever testing brain stimulation treatment (DBS) on Parkinson’s patients.(Medtronic is currently the sole manufacturer of deep brain stimulation equipment, as well as a leader in implantable drug infusion technology.)

Now, Eli Lilly and Medtronic are joining forces to collaborate on a combination therapy for Parkinson’s patients. Together they will conduct research and develop a new approach to treating this debilitating disease using an implantable drug delivery system.

“We believe we have biosynthetically engineered this GDNF variant to overcome technical hurdles of previous research in this area and are hopeful that early testing of our biologic with Medtronic’s device will provide the necessary data to safely advance into human studies,” said Michael Hutton, chief scientific officer of the neurodegeneration team at Lilly, in a statement. “By collaborating with Medtronic from the earliest phase of research, we are maximizing the potential for this therapy’s efficient and effective development.”

Medtronic’s implantable drug delivery system will hopefully allow Lilly’s strength inbiologic, a modified form of glial cell derived neurotrophic factor (GDNF) to cross the blood barrier in the brain, which has thus far been a challenge.

To read the rest of this article, to learn about research, or about the Parkinson Research Foundation, please visit us at http://www.parkinsonresearchfoundation.org/. As always please consult your physician before beginning a new health regime. Our next educational cruise has been planned for January 8th-15th, 2012 and will feature a 1950's sock-hop them, so lace up your shoes...grab your poodle skirts and come dance to the tune of your own beat. Ask youself: When else will you be sailing the open sea with a boat
full of Parkinson experts? PRF employs renowned neurologists,
nutritionists and movement-disorder specialists to educate cruisers
on revolutionary breakthroughs in Parkinson treatment research. As always, please consult your physician before beginning a new diet of health regime. Thank you for your continued support!

Resources:http://www.healthnews.com/Categories/Alerts-Updates/Teaming-Up-to-Develop-Cutting-Edge-Parkinsons-Therapy

Nutritional Guidelines for Parkinon's disease

Nutrition guidelines for Parkinson’s disease...Managing your dietary intake plays an important role in controlling the symptoms of Parkinson’s disease.

Dopamine is an important chemical in the body that helps the nerve cells to communicate thereby enabling muscle co-ordination. The improper brain signalling due to lack of dopamine causes the physical and functional impairment seen in Parkinson’s diseases.Causes of increased risk of PD:

Environmental factors – Industrial and agrarian areas where exposure to toxins are higher have greater incidence of PD

Vitamin E deficiency – Prolonged and severe vitamin E deficiency results in loss of nerve endings that synthesize dopamine.

Dietary lipids – Some experts suggest that high fat intake from animal sources such as red meat, poultry, etc may also cause increased risk of PD

Genetics – There may be a genetic predisposition to developing PD. Women have stronger genetic component than men.

Occupational hazards – Welders and people working in industrialized areas are at greater risk of PD. Also physicians, dentists, teachers, lawyers, scientists, computer programmers are more susceptible than people involved in manufacturing and transportation.

Side effects of medication
Anorexia (loss of appetite)
Nausea
Reduced sense of smell
Constipation
Dry mouth
Dysphagia (difficulty in swallowing)
To overcome these side effects, dopamine should be taken with meals or snacks.

To read the rest of this articles, to learn more about nutrition and health or about the Parkinson Research Foundation, please visit us at http://www.parkinsonresearchfoundation.org/. As always please consult your physician before beginning a new health regime. ur next educational cruise has been planned for January 8th-15th, 2012 and will feature a 1950's sock-hop them, so lace up your shoes...grab your poodle skirts and come dance to the tune of your own beat. Ask youself: When else will you be sailing the open sea with a boat
full of Parkinson experts? PRF employs renowned neurologists,
nutritionists and movement-disorder specialists to educate cruisers
on revolutionary breakthroughs in Parkinson treatment research. As always, please consult your physician before beginning a new diet of health regime. Thank you for your continued support!

Resources:http://mumbaimirror.com/article/9/201104112011041115091742697529dbd/Nutrition-guidelines-for-Parkinson%E2%80%99s-disease.html
Written by: Pooja Singhania

Treatments and Experiments for Parkinson's disease...

Emerging Restorative Treatments for Parkinson's Disease: Manipulation and Inducement of Dopaminergic Neurons from Adult Stem Cells.To address this problem, various types of stem cells that have potential to differentiate into DA neurons are being investigated as cellular therapies for PD, including cells derived from embryonic or adult donor tissue, and embryonic stem cells.

These cell sources, however, have raised certain questions with regard to ethical and rejection issues. Recent progress in adult stems has further proved that the cells derived from adult tissue could be expanded and differentiated into DA precursor cells in vitro, and cell therapy with adult stem cells could produce a clear improvement for PD models. Using adult stem cells for clinic application may not only overcome the ethical problem inherent in using human fetal tissue or embryonic stem cells, but also open the possibility for autologous transplantation. The patient-specific adult stem cell is therefore a potential and prospective candidate for PD treatment.

To learn more about treatments and experiments or about the Parkinson Research Foundation, please visit us at http://www.parkinsonresearchfoundation.org/. As always please consult your physician before beginning a new health regime. ur next educational cruise has been planned for January 8th-15th, 2012 and will feature a 1950's sock-hop them, so lace up your shoes...grab your poodle skirts and come dance to the tune of your own beat.

Ask youself: When else will you be sailing the open sea with a boat
full of Parkinson experts? PRF employs renowned neurologists,
nutritionists and movement-disorder specialists to educate cruisers
on revolutionary breakthroughs in Parkinson treatment research. As always, please consult your physician before beginning a new diet of health regime. Thank you for your continued support!

Resources:http://www.ncbi.nlm.nih.gov/pubmed/21495964

Tango for Parkinson's Disease...

Many recent studies have shown that this form of dance helps patients improve their gait, balance, and mobility; while improving their relationships with their partners.Research has shown that performing the Argentine Tango, a partnered dance based on walking, improves the balance and gait of Parkinson's patients, according to a Robert Wood Johnson University Hospital news release about the class.

Eight couples attended the April 9 class in the Funktion Dance Complex on Route 1 in the Monmouth Junction section of the township. Pall told her students to keep their hips balanced and sturdy, while imagining their torsos were separate and light. The leading partner was to project where they would step next, and then step into space occupied by their partner as the partner stepped away, hopefully in sync.

Recent research has shown that dance, specifically tango, may be an appropriate and effective strategy for ameliorating functional mobility deficits in people who are frail and elderly. Individuals with Parkinson's disease (PD) experience declines in functional mobility that may be even more pronounced than those experienced by frail elderly individuals without PD.

Patients with Parkinson's disease who took part in regular tango dance classes for 20 sessions showed significant improvements in balance and mobility when compared to patients who did conventional exercise, a new study by researchers at Washington University School of Medicine in St. Louis shows.

To learn more about exercise or about the Parkinson Research Foundation, please visit us at http://www.parkinsonresearchfoundation.org/. As always please consult your physician before beginning a new health regime. ur next educational cruise has been planned for January 8th-15th, 2012 and will feature a 1950's sock-hop them, so lace up your shoes...grab your poodle skirts and come dance to the tune of your own beat. Ask youself: When else will you be sailing the open sea with a boat
full of Parkinson experts? PRF employs renowned neurologists,
nutritionists and movement-disorder specialists to educate cruisers
on revolutionary breakthroughs in Parkinson treatment research. As always, please consult your physician before beginning a new diet of health regime. Thank you for your continued support!

Resources:http://www.mycentraljersey.com/article/20110419/NJNEWS/104190340/Parkinson-s-patients-spouses-tango-to-improve-balance
http://www.ncbi.nlm.nih.gov/pubmed/18172414
http://www.michaeljfox.org/newsEvents_parkinsonsInTheNews_article.cfm?ID=292

Mental Health and Parkinson's Disease

Mental health experts join forces to increase public awareness about stress and the importance of good mental health. Research suggests that the modern diet has created nutritional imbalances that may adversely affect our mental health. Not eating enough fresh foods and consuming too many processed foods containing unhealthy fats and sugars is leading to depression, anxiety, memory problems, stress related and other mental disorders.Food can affect how your brain functions in several ways.Sixty per cent of the dry weight of the brain is fat, including the Essential Fatty Acids (EFA's) like Omega-3 fats. These are good fats, and, unfortunately, are in short supply in the modern western diet. EFA's are important components of nerve cell membranes and are involved in the electrical and chemical activity in the brain.

Lack of these fats can cause the brain to malfunction and promote mental illness.Many vitamins and minerals are essential for normal brain function. For example, Niacin (vitamin B3) can affect the activity of the brain and may play a role in schizophrenia and Parkinson's disease.

For more information about nutrition or to learn about Parkinson's disease, please visit us on the web at http://www.parkinsonresearchfoundation.org/ Our next educational cruise has been planned for January 8th-15th, 2012 and will feature a 1950's sock-hop them, so lace up your shoes...grab your poodle skirts and come dance to the tune of your own beat. Ask youself: When else will you be sailing the open sea with a boat
full of Parkinson experts? PRF employs renowned neurologists,
nutritionists and movement-disorder specialists to educate cruisers
on revolutionary breakthroughs in Parkinson treatment research. As always, please consult your physician before beginning a new diet of health regime. Thank you for your continued support!
Resources:http://jamaica-gleaner.com/gleaner/20110412/news/news4.html

PD and Occupational Awareness Month

You know that April is Parkinson's Awareness Month...But did you also know that it's designated Occupational Therapy Awareness Month? "Occupational Therapy focuses on developing a child or adult's ability to perform activities of daily life by restoring or enhancing function lost, due to injury, disease, aging, delayed development or congenital abnormality," Cornelius said.‎

"In adults, OT works to restore functional activities of life to include basics, such as dressing and feeding, to higher tasks, such as driving and household management," Cornelius said. "They also provide home assessments, wheel chair positioning, splinting and recommend adaptive equipment."

According to the American Occupational Therapy Association, several conditions can be treated with OT, such as Alzheimer's, carpal tunnel, cerebral palsy, fibromyalgia, hand injuries, mood disorders, Parkinson's disease, schizophrenia and traumatic brain injury.

To learn more about Occupational Therapy, Parkinson's disease, awareness and advocacy efforts, please visit our website at http://www.parkinsonresearchfoundation.org/. Together we can fight PD! As always please consult your physician before beginning a new regime. To learn more about our upcoming Parkinson's 1950's themed Educational Cruise visit us online or call (941) 870-4438. Thank you for your continued support!

Parkinson’s Disease: Mobility for PD Patients

PARKINSON’S DISEASE: NEUROPROTECTION AND DRUGS OF THE FUTURE

FIFTH ANNUAL PRF PARKINSON’S DISEASE CONFERENCE

MOBILITY FOR PD PATIENTS

Tampa Westshore Marriott - Tampa, Florida

Monday, March 28, 2011

Program Chair: Dr. Juan Sanchez-Ramos

On March 28, 2011, the Parkinson Research Foundation (PRF) will host its annual spring educational conference in Tampa, Florida. The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication, and treatment innovations that greatly improve quality of life. The conference also provides an open forum for patients and caregivers to share their concerns and successes with Parkinson’s experts, and each other.

PRF announced that the 2011 spring educational conference features mobility expert Jeanne Csuy, a notable educator in the movement disorder field. Ms Csuy received her Master’s of Science in Health Education from Gulf Coast University in 2005. In 2008, she collaborated with John Argue, to create the “Parkinson’s Disease & Activities of Daily Living” DVD. This DVD offers solutions to everyday difficulties faced by Parkinson’s patients, including techniques to transition from sitting to standing, bed mobility exercises, and walking techniques that help minimize falls. Ms. Csuy told PRF her main goal in creating the DVD was to “help patients take back their strength.”

“There’s something empowering about regaining your skills you thought you’d lost,” Ms. Csuy told Parkinson’s patients in a recent mobility presentation, “Don’t let anyone do something for you that you can do yourself, maintaining that physical capability offers you a mental toughness that is essential for enduring Parkinson’s disease.” Ms. Csuy provides community education to healthcare professionals and Parkinson’s patients. She is the Hope Parkinson Program Coordinator and credited with developing several community programs designed to assist Parkinson’s patients in Southwest Florida.

The spring educational conference will have general session presentations, including Ms. Cusy’s Mobility Presentation, beginning in the morning followed by breakout workshops in the afternoon, exhibition sessions during the sponsored snack breaks, and a question and answer session at the end of every speaker’s session.

Morning Sessions will include:
• Non-Motor Symptoms of Parkinson’s disease
• Treatments of the Future

Afternoon Workshops include:
• Mobility
• Voice Aerobics TM
• Dance for Parkinson’s disease
• Nutrition

About the Parkinson Research Foundation (PRF)

The Parkinson Research Foundation (PRF) is a nonprofit health organization providing Parkinson’s patients with access to research, education, information and advocacy. PRF distinguishes itself from other Parkinson organizations by focusing on education and awareness, not only for patients, but also for families and caregivers. PRF explores a variety of issues affecting the care and treatment of Parkinson’s disease, with a goal of bringing new advances in treatment to the forefront by, making this knowledge widely available through seminars and conferences.

The money raised by PRF funds research, information programs, and advocacy and awareness efforts that support the over one million people with Parkinson's disease in communities across America.

For more information about PRF or to register for this March 28, 2011 conference, please contact Ms. Rosa Seminario at rseminario@parkinsonresearchfoundation.org or call (800) 869-1551 ext. 0. Thank you for your interest and support.

Gene Therapy Successful in Treating Parkinson’s disease in Second Phase of Clinical Trial

In a first successful Phase II clinical trial, funded by Neurologix, Inc, researchers used a gene therapy called NLX-P101 to reverse symptoms of Parkinson’s disease. The success of the gene therapy is the result of 20 years of research and the first to be used for Parkinson’s disease or any neurological disorder. Gene therapy normalizes chemical signals in Parkinson’s disease
The gene therapy works by normalizing chemical signals in the brain, eliminating symptoms of tremor, stiffness and difficulty moving. Typically, patients with the disease walk with a shuffling gait, finding it difficult to pick up their feet from rigidity of the limbs.

The treatment uses a gene known as glutamic acid decarboxylase (GAD). An inert virus is used to get the gene into the brain. GAD then signals brain cells to produce GABA that binds to the brain’s neurons, normalizing defects found in patients with Parkinson’s disease.

As a control, patients were given a sham therapy while they wereawake so they could respond to commands to move their limbs from the researchers, making them believe they were receiving the gene therapy. The control group was also given a saline injection instead of the gene, using the same delivery system as the therapy group.

The findings are published in the Lancet Neurology that could be a major advance for treating Parkinson’s disease, but longer trials would be needed to assess safety of the treatment.

In the study, the gene therapy dramatically improved symptoms of Parkinson’s disease in over half of the patients, compared to 14 percent of the control group at six months, with improvement seen at one month. Dr. During says the success of the Phase II trial means the NLX-P101 therapy is closer to being used in clinical practice for treatment of the debilitating neurological disorder. Neurologix, Inc., co-founded by Dr. Kaplitt, is seeking FDA approval for a Phase III clinical trial.

To learn more about How to Fight Parkinson's disease, we invite you to attend our educational conference on Monday, March 28th, 2011 at the Tampa Westshore Marriott in Tampa, Florida.

The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication and treatment innovations that greatly improve quality of life.

To learn more about the conference or the Parkinson Research Foundation, please visit us at http://parkinsonresearchfoundation.org/ As always please consult your physician before beginning a new health regimen. Thank you for your continued support.

References: http://www.emaxhealth.com/1020/gene-therapy-treats-parkinson%E2%80%99s-disease-second-clinical-trial

If I have Parkinson's disease...Should I Get a Nutritionist?

It is always good to seek the professional advice of a nutritionist right after your Parkinson's Disease diagnosis so that you can get some solid information on what to eat and what to avoid. Most health care plans cover consultations with nutritionists so it will not cost you any extra money (except the co-pay). The nutritionist can take into account all of your special circumstances.

Perhaps you have other conditions (e.g. high blood pressure or diabetes) that require special diets. The nutritionist can help you to decide what if any new foods to add to or to drop from your existing diet. Ask your neurologist to refer you to a good nutritionist and get some solid information on how to eat right when you have PD.

To learn more about How to Fight Parkinson's disease and nutrition, we invite you to attend our educational conference on Monday, March 28th, 2011 at the Tampa Westshore Marriott in Tampa, Florida.

The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication and treatment innovations that greatly improve quality of life.

To learn more about the conference or the Parkinson Research Foundation, please visit us at http://parkinsonresearchfoundation.org/ As always please consult your physician before beginning a new health regimen. Thank you for your continued support.

References: Weiner, W. J., Shulman, L.M. and Lang, A. E. (2007). Parkinsons Disease, Second Edition, A Complete guide for patients and families. Johns Hopkins Press Book, Baltimore.

Brain Stimulation, New Treatment for Many Parkinson's Patients...

Not everyone with Parkinson's is eligible for deep-brain stimulation, which has been available in the United States in various forms since the late 1990s. But the latest version of the $65,000 procedure, approved by the Food and Drug Administration for Parkinson's in 2002, can offer patients significant relief of symptoms and less need for high doses of medicine to cope with one of the most common nervous-system disorders in older adults.

"These are the happiest patients I have," said Cozzens, chairman of SIU's neurosurgery division. "They're thrilled with the results. They get their life back."

Cozzens, 58, a Chicago-area native who was trained at Northwestern University's medical school, brought deep-brain stimulation to Springfield. He has performed about 300 of the procedures in his career, making him one of the most experienced practitioners in Illinois.

Deep-brain stimulation also can be used to treat chronic pain, and research is under way on its use in treating depression, Tourette syndrome, high blood pressure and even obsessive-compulsive disorder.

But the most proven benefits are in patients with Parkinson's and other movement disorders, Cozzens said. So at least for now, those are the only patients receiving the procedure in Springfield.

Deep-brain stimulation works by scrambling the abnormal brain signals that cause Parkinson's symptoms, but it hasn't been proven to halt the progression of the disease itself.

Because of the risk of infection, stroke and brain damage, deep-brain stimulation is considered only when medicine isn't working well to ease the tremors, limb stiffness, slow movement and coordination problems caused by Parkinson's, Elble said.

Elble, who works with Cozzens, said patients must be selected carefully.

"Some people who come to us have been misdiagnosed," Elble said. "Some people have never been given adequate trials of medicine."

About 20 percent of Parkinson's patients - often those younger than 60 or those whose primary symptoms are tremors - could benefit from deep-brain stimulation, Elble said.

But 90 percent of his patients have seen at least some improvement, and 80 percent have experienced major improvements, he said.

*What is it: A surgical procedure to treat a variety of disabling neurological symptoms, most commonly symptoms of Parkinson's disease.

*What happens during surgery: A battery-operated device similar to a heart pacemaker is surgically implanted to deliver electrical stimulation to targeted areas in the brain that control movement, blocking the abnormal nerve signals that cause tremors and other Parkinson's symptoms. Patients don't feel the insertion of the electrode or the electrical current because nerve cells in brain tissue don't detect pain.

*Cost of the surgery: About $65,000. The procedure is covered by Medicare and Medicaid and is commonly covered by private insurance.

*Risks: Infection, allergic reaction, dizziness, speech or vision problems, stroke and other brain damage.

*About Parkinson's: 50,000 to 60,000 new cases of Parkinson's are diagnosed in the United States each year, and 1 million Americans have the disease, for which there is no cure. An estimated 20 percent of Parkinson's patients could benefit from deep-brain stimulation.

To learn more about How to Fight Parkinson's disease, we invite you to attend our educational conference on Monday, March 28th, 2011 at the Tampa Westshore Marriott in Tampa, Florida.

The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication and treatment innovations that greatly improve quality of life.

To learn more about the conference or the Parkinson Research Foundation, please visit us at http://parkinsonresearchfoundation.org/ As always please consult your physician before beginning a new health regimen. Thank you for your continued support.

References: http://www.behealthyspringfield.com/sections/local-news/brain-stimulation-new-treatment-for-many-parkinsons-sufferers

Fighting Parkinson's disease with Exercise!

Fighting Parkinson's with Exercise..Six days a week, you can find Jim Patterson at the gym.The tremor in is hands is nothing like it once was. Diagnosed with Parkinson’s disease in 2003, and feeling symptoms as early as the late 1990's, Jim has taken the battle with P.D. head-on.Prior to his P.D., Jim was employed by the F.B.I., working counter-terrorism by conducting surveillance on suspected threats to the U.S. He was even the man they wanted to be the driver while chasing down the bad guys in fast and dangerous situations.

"I’ve been one of 45 people or so that have become an advocate for the association. We encourage clinical trials because less than one percent of the people who have Parkinson’s in America have participated in clinical trials. So, the P.D.F. people have really pushed that and I’m glad to be a member," Patterson continued.

Yes, clinical trials. If a cure is to be found for Parkinson’s and other diseases of the brain, it will most likely come from clinical trials done at places like Sarasota’s Roskamp Institute.

Patterson wants to be there when it happens. "I’m going to continue to exercise, of course, and I’m going to continue to educate the people when I can about Parkinson’s and the need for clinical trials. And, I’m going to go on the journey and keep it up until there’s cure for Parkinson’s.

To learn more about How to Fight Parkinson's disease, we invite you to attend our educational conference on Monday, March 28th, 2011 at the Tampa Westshore Marriott in Tampa, Florida.

The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication and treatment innovations that greatly improve quality of life.

To learn more about the conference or the Parkinson Research Foundation, please visit us at http://parkinsonresearchfoundation.org/ As always please consult your physician before beginning a new health regimen. Thank you for your continued support.

References:http://www.myfoxtampabay.com/dpp/news/local/fighting-parkinson's-with-exercise-031411

Educational Symposium on Parkinson's Disease...

The Parkinson Research Foundation cordially invites you to our annual Parkinson’s disease educational conference. This year’s conference will be held on March 28th, 2011 at the Tampa Westshore Marriott in Tampa, Florida.The conference is a unique educational opportunity for Parkinson’s disease (PD) patients, families, and caregivers to learn about the latest advances in PD research, medication and treatment innovations that greatly improve quality of life.

What makes our event unique? Participation! We complement informational presentations from leaders in the Parkinson’s field with interactive elements, encouraging attendees to share questions, concerns, and ideas with nationally known Parkinson’s experts, local doctors, fellow patients and caregivers. Useful hands-on workshops such as “Mobility for PD patients” and “Voice AerobicsTM” will present time-tested techniques and ideas that encourage a more active and comfortable lifestyle for PD patients.

The conference will run from 9:00am-4:30pm with registration beginning at 8:00am. Speakers and presenters include some of the most notable and prominent names in the Parkinson’s community, including Conference Chair, Dr. Juan Sanchez-Ramos, Dr. Robert Hauser and several others.

To register or for more information about the March 26th Educational Conference, please contact Ms. Rosa Seminario at: rseminario@parkinsonresearchfoundation.org or call (800) 869-1551 ext. 0. I look forward to seeing you at the conference. To learn more about the Parkinson Research Foundation, please visit us online at http://www.parkinsonresearchfoundation.org/. We look forward to seeing you at our educational conference. Thank you for your continued support!

A Major Breakthrough in Parkinson's Research....Could This Really be the Medication to Stop the Progression?

A major breakthrough in Parkinson's research could lead to the development of a drug able to stop the progression of the neurodegenerative condition.A drug has been found to halt the progression of Parkinson's disease in mice and is now being tested on humans, scientists have said.Research published online in the Journal of Biological Chemistry found that the drug phenylbutyrate switches on a gene which is able to protect dopamine neurons in people with Parkinson's disease."Drugs currently used to treat Parkinson's disease just treat symptoms; they do not stop the disease from getting worse," said senior author Curt Freed, MD, who heads the division of Clinical Pharmacology and Toxicology at the CU School of Medicine. "We've now discovered that we can prevent the progression of the disease by turning on a protective gene in the brain."

Lead author Wenbo Zhou, PhD, Assistant Professor of Medicine, and Freed, a national pioneer in Parkinson's research, have found that the drug phenylbutyrate turns on a gene that can protect dopamine neurons in Parkinson's disease. The gene, called DJ-1, can increase production of antioxidants like glutathione to reduce the debilitating effects of excess oxygen in brain cells. In addition, activating DJ-1 helps cells eliminate abnormal proteins that otherwise accumulate and kill brain cells. Dopamine neurons are particularly susceptible to too much oxygen and abnormal protein deposits. Parkinson's disease is caused by dying midbrain dopamine neurons.

Zhou and Freed have studied the DJ-1 gene since 2003 when a European group discovered that mutations in DJ-1 could cause Parkinson's disease. The Colorado scientists immediately started work to see why the gene was so important and have published a series of papers on the subject since 2005. But to convert their findings into a practical treatment for Parkinson's disease, they needed to find a drug to turn on the DJ-1 gene.

After testing many drugs, the team found that phenylbutyrate could activate DJ-1 and keep dopamine neurons from dying. Next, they put the drug in the drinking water of mice genetically programmed to get Parkinson's disease as they aged.

Aging mice receiving the drug were able to move normally, had no decline in mental function, and their brains did not accumulate the protein that causes Parkinson's. By contrast, older animals that did not get the drug saw a steady decline in their ability to move as their brains were damaged by abnormal proteins.

The researchers began giving phenylbutyrate to people in 2009, to test the safety of the drug in Parkinson patients.

Zhou and Freed will publish the human results in the coming months.

This is exciting and encouraging news in Parkinson's research, please keep checking our Facebook page, our blog, and our website as new information emerges we will share it will everyone. To learn more about about the Parkinson Research Foundation and our mission in educating patients or to learn more about our educational conference on Monday, March 28, 2011 please visit us at http://www.parkinsonresearchfoundation.org/ As always please consult your physician before beginning a new health regimen. Thank you for your continued support.

References: http://www.eurekalert.org/pub_releases/2011-03/uocd-rfd030811.php